What Is Restless Legs Syndrome?
Restless Leg Syndrome (RLS) is a sensory disorder causing an almost irresistible urge to move the legs. The urge to move is usually due to unpleasant feelings in the legs that occur when at rest. People with RLS use words such as creeping, crawling, tingling, or burning to describe these feelings. Moving the legs eases the feelings, but only for a while. The unpleasant feelings may also occur in the arms.
Effects of RLS
RLS can make it hard to fall asleep and stay asleep. People with RLS often don’t get enough sleep and may feel tired and sleepy during the day. This can make it difficult to:
Concentrate, making it harder to learn and remember things
Carry out other usual daily activities
Take part in family and social activities
RLS can range from mild to severe, based on:
How much discomfort you have in your legs and arms
Whether you feel the need to move around
How much relief you get from moving around
How much sleep disturbance you have
How tired or sleepy you are during the day
How often you have symptoms
How severe your symptoms are on most days
How well you carry out daily activities
How angry, depressed, sad, anxious, or irritable you feel
Types of RLS
There are two types of Restless Leg Syndrome:
Primary RLS is the most common type of RLS. It is also called idiopathic RLS. “Primary” means the cause is not known. Primary RLS, once it starts, usually becomes a lifelong condition. Over time, symptoms tend to get worse and occur more often, especially if they began in childhood or early in adult life. In milder cases, there may be long periods of time with no symptoms, or symptoms may last only for a limited time.
Secondary RLS is RLS that is caused by another disease or condition or, sometimes, from taking certain medicines. Symptoms usually go away when the disease or condition improves, or if the medicine is stopped.
Periodic Limb Movement Disorder or Periodic Leg Movements during Sleep
Many people with RLS also have a condition called periodic limb movement disorder (PLMD). PLMD is a condition in which a person’s legs twitch or jerk uncontrollably about every 10 to 60 seconds. This usually happens during sleep. These movements cause repeated awakenings that disturb or reduce sleep. PLMD usually affects the legs but can also affect the arms.
RLS can be unpleasant and uncomfortable. However, there are some simple self-care approaches and lifestyle changes that can help in mild cases. Restless Leg Syndromesymptoms often improve with medical treatment. Research is ongoing to better understand the causes of RLS and to develop better treatments.
What Causes Restless Leg Syndrome?
In most cases of restless legs syndrome (RLS), no cause can be found. When no cause can be found, the condition is called primary RLS. It is known, however, that primary RLS tends to run in families. People whose parents have RLS are more likely to develop the disorder. This suggests that there may be a genetic link that increases the chance of getting RLS.
Secondary RLS is RLS that is caused by another disease or condition, or as a side effect of certain medications. Some of the diseases and conditions that can cause RLS are:
Iron deficiency (with or without anemia)
Damage to the nerves in the hands or feet (peripheral neuropathy) (pe-RIF-e-ral noo-ROP-a-the)
Rheumatoid arthritis (ROO-ma-toyd ar-THRI-tis)
RLS is common in pregnant women. It usually occurs during the last 3 months of pregnancy and usually improves or disappears within a few weeks after delivery. However, some women may continue to have symptoms after giving birth or may develop RLS again later in life.
Some of the types of medicines that can cause RLS are:
Some cold and allergy medicines
RLS symptoms usually go away when the medicine is stopped.
Certain substances can trigger RLS symptoms or make them worse. These substances include:
Who Is At Risk for Restless Leg Syndrome?
Restless Leg Syndrome (RLS) may affect as many as 12 million people in the United States.
RLS affects both men and women. The disorder occurs more often in women than in men.
The number of cases of RLS rises with age. Many people with RLS are diagnosed in middle age. But in up to two out of every five cases, the symptoms of RLS begin before age 20. People who develop RLS early in life usually have a family history of the disorder.
RLS can affect people of any race or ethnic group. The disorder is more common in persons of northern European descent.
RLS is common in pregnant women. It usually occurs during the last 3 months of pregnancy and usually improves or disappears within a few weeks after delivery.
What Are the Signs and Symptoms of Restless Legs Syndrome?
Restless legs syndrome (RLS) has several major signs and symptoms:
An almost irresistible urge to move the legs or arms when sitting or lying down
An unpleasant feeling in the legs
Difficulty falling asleep or staying asleep because of the unpleasant feelings in the legs or arms
Daytime sleepiness, which results from a lack of restful sleep due to the repeated limb movements
Urge To Move
RLS gets its name from the urge to move the legs when sitting or lying down. This urge is due to unpleasant feelings in the legs that are relieved by movement. Typical movements are:
Pacing and walking
Jiggling the legs
Stretching and flexing
Tossing and turning
Rubbing the legs
The urge to move the legs usually is due to unpleasant feelings in the legs. People with RLS describe these feelings as:
Hard to describe
Children may describe RLS symptoms differently than adults.
The unpleasant feelings in RLS usually occur in the lower leg (calf). But the feelings can occur at any place between the thigh and the ankle and also in the arm. The feelings are worse:
When lying down or sitting for a long period of time
During the evening or night, more so than during the day
The unpleasant feelings also:
Make it hard to fall asleep or stay asleep
Are not as bad or go away when you move
Duration and Severity
RLS symptoms tend to get worse over time. They may begin in childhood and develop slowly over several years. People with early symptoms are more likely to have other family members with RLS than people who develop RLS later in life.
Symptoms tend to worsen faster when RLS occurs later in life. RLS that occurs later in life is also more likely to result from an underlying condition or illness than RLS that occurs early in life.
People with mild symptoms may only notice them when they are still or awake for a long time, such as on a long airplane trip.
How Is Restless Legs Syndrome Diagnosed?
The way that you describe your symptoms is very important in diagnosing restless legs syndrome (RLS). Your doctor will:
Take a complete medical history
Do a complete physical examination
Order other tests
The diagnosis of RLS usually requires the following four conditions be present:
An urge to move the legs due to an unpleasant feeling in the legs.
The urge to move the legs, or the unpleasant feelings in the legs, begins or gets worse when you are at rest or not moving around frequently.
The urge to move the legs, or the unpleasant feelings in the legs, is partly or completely relieved by movement (such as walking or stretching) for as long as the movement continues.
The urge to move the legs, or the unpleasant feelings in the legs, is worse in the evening and at night, or only occurs in the evening or at night.
Your doctor will take a medical history and ask questions such as:
Can you describe your symptoms?
When did your symptoms first begin?
When during the day or night do the symptoms usually occur?
When are your symptoms worse?
Do symptoms interfere with your sleep?
Your doctor will also ask about your sleep habits, such as:
The time you go to bed and get up
Your routine before going to bed
Noise, light, and interruptions in the room where you sleep
Whether you snore
Your doctor will ask about how you feel during the day, including whether:
You are tired and sleepy when you wake up and during the day.
You have trouble concentrating.
You doze off or have difficulty staying awake doing routine tasks, especially driving.
Your doctor will ask questions to find out if your symptoms are a result of a possible underlying condition. Questions might include:
Do members of your family have similar symptoms?
What medicines (over-the-counter and prescription) do you take?
Do you snore loudly and frequently?
Do you gasp for air during sleep?
Do you use caffeine, tobacco, or alcohol?
A physical exam is done to:
Identify any underlying condition that may cause RLS
Rule out other disorders
Your doctor also will pay special attention to:
The nerves in your spinal cord (especially) and legs and arms
The blood flow in your legs and arms
There is no test currently available to diagnose RLS.
However, blood tests can be used to look for underlying conditions that can cause RLS. These tests check for:
Low iron stores or iron deficiency
Other vitamin and mineral deficiencies
How Is Restless Legs Syndrome Treated?
The goals of treatment for restless legs syndrome (RLS) are to:
Increase the amount and quality of sleep
Treat or correct any underlying condition that may cause RLS
Types of treatment include:
Lifestyle changes and other nondrug treatments
Lifestyle changes can improve and relieve symptoms of RLS. Lifestyle changes may be the only treatment needed for mild RLS. Some lifestyle changes that may help include:
Avoid things that can make symptoms of RLS worse:
Caffeine—Chocolate, coffee, tea, and some soft drinks contain caffeine. Although it may seem to help overcome daytime sleepiness, caffeine usually only delays or masks RLS symptoms, and often makes them worse.
Some medicines—Some types of over-the-counter and prescription medicines can also make RLS symptoms worse. These include:
Antidepressants (most of them)
Adopt good sleep habits:
Keep your bedroom or sleep area cool, quiet, comfortable, and free of unnecessary light.
Use your bedroom for sleeping, not for watching TV or using computers or cell phones.
Go to bed every night at the same time and wake up at the same time every morning. Some people with RLS find it helpful to go to bed later in the evening and get up later in the morning. The important thing is to get enough sleep so that you feel rested when you wake up.
Follow a program of moderate exercise
Other activities that also may help relieve symptoms include:
Walking or stretching
Taking a hot or cold bath
Massaging the leg or arm
Using heat or ice packs
Medicines can help relieve some symptoms of RLS. Doctors prescribe medicines to treat RLS in people:
With clearly defined symptoms
Whose symptoms cannot be controlled by lifestyle and nondrug treatments
No single medicine is helpful in all persons with RLS. It may take several changes in medicines and dosages to find the best approach. Sometimes, a medicine will work for a while and then stop working.
Some medicines may not be safe for pregnant women.
Always talk with your doctor before taking any medicines, even over-the-counter medicines.
Medicines used to treat Parkinson’s disease also are used to treat RLS. Even though these medicines help reduce RLS symptoms, RLS is not a form of Parkinson’s disease. The medicines help reduce the amount of motion in the legs. They include:
Is best used to treat mild cases of RLS
Works for a while but does not work long term in most people
Dopamine agonists (pergolide (PER-go-lid), pramipexole (prah-mih-PEX-ohl), and ropinirole (roh-PIN-ih-roll))
Are used to treat moderate and severe cases of RLS
Are used to treat mild cases of RLS if levodopa stops working
The U.S. Food and Drug Administration recently approved ropinirole to treat moderate to severe RLS.
Other medicines may be used to treat RLS, including:
Strong pain-relieving medicines (narcotics).
Used most often when symptoms are severe
May be used in people who don’t respond to dopamine agonists
Sedatives (benzodiazepines (BEN-so-di-AZ-e-pens)).
Help with falling asleep
May cause daytime sleepiness
Are not recommended for people with sleep apnea and for older persons
Medicines used to treat epilepsy (anticonvulsants: gabapentin (gab-ah-PEN-tin), carbamazepine (kar-bam-AZ-e-pen), and valproate (val-PROH-ate)). These types of medicines are:
Considered when dopamine agonists fail
Most effective in persons with daytime and evening symptoms, as well as sleep-onset symptoms, and in those who describe the unpleasant feelings in the legs as painful.
Iron supplements, if iron deficiency appears to be contributing to RLS. Iron supplements should only be used if recommended by a doctor.
Above courtesy of NHLBI
Below – original contribution.
Restless legs syndrome (RLS)is a condition in which the individual has a strong, often uncontrollable urge to move their legs. This is brought on by undefined sensations in the legs that many sufferers have difficulty explaining in comparison to other sensations. It has been described as feelings of electric currents running through the legs, prickling, itching or burning sensations, tingling, and on occasion is brought on by no concrete sensation at all.
Though the syndrome is largely confined to the legs, some people may also experience it in the arms, or in very rare cases, other areas of the body. It is typically worse at night, and often strikes while lying in bed, but can occur at any time, usually during periods of inactivity such as long stretches of travel, watching T.V, or out at the theatre or a concert where you are seated for long stretches.
Its occurrence just before or during sleep can severely hamper quality sleep time, as many people are prone to suffer through it in bed, alternating between sleep and wakefulness brought on by the sensations, and hope it goes away rather than get up and walk around to try and eliminate it. Severe cases on RLS can cut quality sleep time in half.
Despite this, RLS remains largely misunderstood by doctors, who have had difficulty both in classifying and diagnosing it. There is some debate other whether restless legs syndrome is even its own legitimate entity, or if it should rather fall under another broader category such as being classified as a sympathetic nervous system (SNS) response, similar to the feeling of the hair on the back of your neck rising, or getting ‘goosebumps’ not caused by external factors. These are generally felt in reaction to the mindset of the individual. This relating of RLS and SNS is not widely accepted though.
Most people report immediate relief by getting up and moving about or stretching, and others have said drinking water calms its effects, leading some doctors to theorize that dehydration may play a part in its appearance. Some people may experience RLS frequently, while others will experience it sporadically or rarely. Some people may even go years between episodes of RLS. In most cases, the RLS will become more frequent over time though.
Approximately 2.5% of adults have RLS on a fairly regular basis, and as many as 10% of adults experience it occasionally, or have in the past. Higher incidence rates are found among those with family members who have also had RLS, as high as 40%. The syndrome has been found to be rare in many Asian countries which could indicate that diet or other factors, such as genetic makeup may play a role in the occurrence of restless legs syndrome. RLS can also strike children, and is often misdiagnosed as either ‘growing pains’ in young teens, or hyperactivity in younger kids. RLS also has a much higher incidence rate in females than in males.
RLS is also highly tied to periodic limb movements (PLM), with 85% of those with RLS also having incidences of PLM. PLM is undesired flexing or tightening of the leg muscles, which can be painful in some cases. It can also come in the form of automatic movements of the legs, which can’t be controlled. PLM and RLS symptoms may appear together at the same time, but are more likely to appear separately on different occasions.
Mild RLS occurrence has been tied directly to other medical conditions, and usually disappears after the associated condition is cleared up. These include pregnancy, kidney disease, iron deficiency and any conditions that cause low levels of iron, peripheral neuropathy and some medications, including anti-nausea and depressant medications.
Someone suffering regular occurrences of RLS, especially during bedtime should consult a doctor. The doctor can have a blood test taken to check your iron levels, and may be able to suggest other factors that could be contributing to your occurrence rate of RLS.
There are a few medical treatments for RLS. Those with low iron levels, or one of the medical conditions above that may be causing it, may be encouraged to remedy these problems. This may include a balanced exercise regimen (not too much, or too little, as both can aggravate RLS), decreasing or eliminating caffeine, tobacco and alcohol consumption, and improving general diet with supplements like potassium, magnesium and calcium. As alluded to, iron replacement has been demonstrated to improve symptoms in many.
Dopamine agonist medications have demonstrated much success in the treatment of RLS.
Other activities that may help symptoms or Restless Leg Syndrome include taking a hot baths, soaking feet in hot water near bed time, keeping your mind engrossed or busy while physically inactive, placing a pillow or other object between your legs while you sleep, and drinking green tea.
Reviewed September, 2007